Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.

Abstract

Data are presented for the serum levels of 2-ethyl-2-phenylmalonamide (PEMA) in patients receiving anticonvulsant medication. Statistical analysis of these data indicates that the serum level of PEMA, which is a metabolite of primidone, is affected not only by the dose of primidone but also by the serum levels of other prescribed anticonvulsant drugs. In particular, phenobarbitone is shown to be a major perturbation upon the PEMA serum level.

Cite this paper

@article{Streete1986PhenylethylmalonamideSL, title={Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.}, author={J. M. Streete and Dave Berry and L. I. Pettit and James Newbery}, journal={Therapeutic drug monitoring}, year={1986}, volume={8 2}, pages={161-5} }