Phenylethylamide derivatives of the C-terminal tetrapeptide of gastrin. Potent inhibitors of gastrin-stimulated acid secretion.

@article{Martnez1986PhenylethylamideDO,
  title={Phenylethylamide derivatives of the C-terminal tetrapeptide of gastrin. Potent inhibitors of gastrin-stimulated acid secretion.},
  author={Jean Mart{\'i}nez and Mareli Rodriguez and Jean Pierre Bali and J Laur},
  journal={International journal of peptide and protein research},
  year={1986},
  volume={28 5},
  pages={529-35}
}
Peptide analogues of the C-terminal tetrapeptide of gastrin in which the phenylalanine had been replaced were synthesized and their biological activity on acid secretion evaluated. Compounds Boc-Trp-Leu-Asp phenylethylamide 6, Boc-beta-Ala-Trp-Leu-Asp phenylethylamide 9, Boc-Trp-Leu-Asp p-fluorophenylethylamide 19, Boc-Trp-psi(CH2NH)-Leu-Asp… CONTINUE READING