Phenylethanolamine N-methyltransferase gene polymorphisms and adverse outcomes in acute kidney injury.

@article{Alam2010PhenylethanolamineNG,
  title={Phenylethanolamine N-methyltransferase gene polymorphisms and adverse outcomes in acute kidney injury.},
  author={A. K. M. Rezaul Alam and Daniel T. O'Connor and Mary C. Perianayagam and Alexey Y Kolyada and Yuqing Chen and Fangwen Rao and Manjula Mahata and Sushil K Mahata and Orfeas Liangos and Bertrand L. Jaber},
  journal={Nephron. Clinical practice},
  year={2010},
  volume={114 4},
  pages={c253-9}
}
BACKGROUND/AIMS The catecholaminergic pathway is important in the physical stress response; however, its role is not well understood in acute kidney injury (AKI). We studied single nucleotide polymorphisms (SNPs) of phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholaminergic pathway, and their association with adverse outcomes in AKI. METHODS We performed a case-control study of 961 Caucasian subjects (194 with AKI and 767 controls). The PNMT promoter G-161A… CONTINUE READING