Phenylephrine-induced antinociception: investigations of potential neural and endocrine bases

@article{Watkins1990PhenylephrineinducedAI,
  title={Phenylephrine-induced antinociception: investigations of potential neural and endocrine bases},
  author={Linda R Watkins and Cindy L. Thurston and Monika Fleshner},
  journal={Brain Research},
  year={1990},
  volume={528},
  pages={273-284}
}
Acute hypertensive states can produce antinociception, largely via unknown mechanisms. The aim of the present series of experiments was to examine potential hormonal and neural bases of analgesia induced by i.v. infusion of the pressor (hypertensive) agent phenylephrine. All rats were implanted with right jugular and left carotid cannulae for phenylephrine infusion and blood pressure/heart rate monitoring, respectively, and were tested approximately 24 h later in the unanesthetized state. The… CONTINUE READING
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