Phenylbutyric acid prevents rats from electroconvulsion-induced memory deficit with alterations of memory-related proteins and tau hyperphosphorylation

@article{Yao2010PhenylbutyricAP,
  title={Phenylbutyric acid prevents rats from electroconvulsion-induced memory deficit with alterations of memory-related proteins and tau hyperphosphorylation},
  author={Zhimo Yao and Zihu Guo and Chenxi Yang and Qi Tian and Jane Wang},
  journal={Neuroscience},
  year={2010},
  volume={168},
  pages={405-415}
}
Electroconvulsive therapy has been commonly applied in the treatment of refractory depression, but its cognitive side effects are noticed and restrict its application. The molecular mechanisms underlying the side effects remain elusive, and there is no efficient prevention. By employing a recognized electroconvulsive shock (ECS) rat model, we found in the present study that ECS induced spatial memory deficits with simultaneous decreases in synaptic proteins of N-methyl-D-aspartate receptor 2A/B… CONTINUE READING
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The Arc of synaptic memory

CR ramham, MN Alme, +8 authors K Wibrand
  • Exp Brain Res
  • 2010

Endoplasmic reticulum stress plays a central role in development of leptin resistance

L zcan, AS Ergin, +5 authors U Ozcan
  • Cell Metab
  • 2009

Differential expression of synaptic vesicle proteins after repeated electroconvulsive seizures in rat frontal cortex and hippocampus

B lfving, BE Bonefeld, R Rosenberg, G Wegener
  • Synapse
  • 2008

GSK - 3 beta is required for memory reconsolidation in adult brain

E Real, HW Kessels, R Malinow
  • PLoS One
  • 2008