Phenylbutazone increases right atrial pressure and heart rate of running horses.

@article{Mitten1996PhenylbutazoneIR,
  title={Phenylbutazone increases right atrial pressure and heart rate of running horses.},
  author={Lisa Mitten and K W Hinchcliff and Joy L Pate},
  journal={Journal of applied physiology},
  year={1996},
  volume={81 1},
  pages={312-7}
}
The effect of inhibition of cyclooxygenase activity on the hemodynamic response to exertion was examined in 6 horses. Rates of O2 consumption and CO2 production and carotid, pulmonary arterial, and right atrial pressures were measured while the horses performed a standardized exercise test on a treadmill after treatment with phenylbutazone or a placebo. Phenylbutazone (8.8 mg/kg p.o. for 2 days and 4.4 mg/kg i.v. 60 min before exertion) abolished the exertion-induced increases in plasma 6… CONTINUE READING