Phenylbutazone and oxyphenbutazone distribution into tissue fluids in the horse.

  title={Phenylbutazone and oxyphenbutazone distribution into tissue fluids in the horse.},
  author={Peter D Lees and Jamie Beavers Taylor and Andrew J. Higgins and S Chidananda Sharma},
  journal={Journal of veterinary pharmacology and therapeutics},
  volume={9 2},
The clinically recommended dose rate of phenylbutazone (4.4 mg/kg) was administered intravenously as a single dose to five Welsh Mountain ponies. Distribution of phenylbutazone and its active metabolite oxyphenbutazone into body fluids was studied by measuring concentrations in plasma, tissue-cage fluid, peritoneal fluid and acute inflammatory exudate harvested from a polyester sponge model of inflammation. The ready penetration of phenylbutazone into inflammatory exudate was demonstrated by… CONTINUE READING


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