Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability.

@article{Bradke2008PhenylboronicAS,
  title={Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability.},
  author={Tiffany M Bradke and Casey Hall and Stephen W. Carper and George E. Plopper},
  journal={Cell adhesion & migration},
  year={2008},
  volume={2 3},
  pages={153-60}
}
We compared the in vitro effect of boric acid (BA) versus phenylboronic acid (PBA) on the migration of prostate and breast cancer cell lines and non-tumorigenic cells from the same tissues. Treatment at 24 hours with BA (< or =500 microM) did not inhibit chemotaxis on fibronectin in any cell line. However, treatment over the same time course with concentrations of PBA as low as 1 muM significantly inhibited cancer cell migration without effecting non-tumorigenic cell lines. The compounds did… CONTINUE READING