Phenylboronic acid--a potent inhibitor of lipase from Oryza sativa.

@article{Raghavendra2002PhenylboronicAP,
  title={Phenylboronic acid--a potent inhibitor of lipase from Oryza sativa.},
  author={Manikanahally P Raghavendra and Vishweshwaraiah Prakash},
  journal={Journal of agricultural and food chemistry},
  year={2002},
  volume={50 21},
  pages={
          6037-41
        }
}
The kinetics of inhibition of rice bran lipase (RBL) by phenylboronic acid (PBA) was studied to elucidate the nature of inhibition and the effect of the inhibitor on the structure-function of RBL. The effectiveness of an inhibitor is normally expressed by the constant K(i), which is calculated from the Lineweaver-Burk plot and found to be 1.7 mM at pH 7.4. The kinetics of inhibition by PBA was competitive, indicating the presence of serine in the active site of the enzyme. The loss of activity… CONTINUE READING

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