Phenylarsine oxide inhibits insulin activation of phosphatidylinositol 3'-kinase.

@article{Han1997PhenylarsineOI,
  title={Phenylarsine oxide inhibits insulin activation of phosphatidylinositol 3'-kinase.},
  author={Yuefeng Han and Ronald A. Kohanski},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={239 1},
  pages={316-21}
}
Two early events downstream of insulin receptor autophosphorylation that are necessary for activation of glucose transport in adipocytes appear to be: (1) The tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) which (2) recruits and activates phosphatidylinositol 3'-kinase (PI3'-K). Phenylarsine oxide (PAO) has long been known to inhibit glucose transport, without inhibiting insulin receptor auto- or substrate phosphorylation. However, the PAO-sensitive site downstream of these… CONTINUE READING