Phenylarsine oxide inhibition of endocytosis: effects on asialofetuin internalization.

  title={Phenylarsine oxide inhibition of endocytosis: effects on asialofetuin internalization.},
  author={Antonio E. Gibson and Richard Joseph Noel and Jeremiah T. Herlihy and Walter F. Ward},
  journal={The American journal of physiology},
  volume={257 2 Pt 1},
The aim of this work was to establish to what extent the concentrations over which phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization. The effects of PAO (1-100 microM) on 125I-labeled asialofetuin internalization, oxygen consumption, ATP content, and lactate dehydrogenase (LDH) latency of isolated rat hepatocytes were determined. Ten micromoles/liter PAO blocked 125I-asialofetuin internalization but… CONTINUE READING

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