Phenylarsine oxide induces apoptosis in Bax and Bak deficient cells through upregulation of Bim Running title: PAO induces Bax/Bak-independent apoptosis

Abstract

Purpose: Bax and Bak are regarded as key mediators for cytochrome c release and apoptosis. Loss of Bax or Bak is often reported in human cancers and renders resistance of these cancerous cells to chemotherapy. Here we investigated that phenylarsine oxide (PAO) could induce Bax/Bak-independent apoptosis. Experimental Design: Annexin V/PI staining, TUNEL… (More)

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