Phenylarsine oxide and hydrogen peroxide stimulate glucose transport via different pathways in isolated cardiac myocytes.

@article{Fischer1993PhenylarsineOA,
  title={Phenylarsine oxide and hydrogen peroxide stimulate glucose transport via different pathways in isolated cardiac myocytes.},
  author={Yvan Fischer and H N Rose and J. -C. Thomas and B. Deuticke and H. Kammermeier},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1153 1},
  pages={97-104}
}
The aim of this study was to investigate the stimulating effects of sulfhydryl reagents on glucose transport in isolated rat heart muscle cells and to compare them with the action of insulin. Low concentrations of the sulfhydryl oxidants hydrogen peroxide (H2O2) and diamide (5-100 microM), but also of phenylarsine oxide (PAO) (0.5-3 microM), that is known to specifically react with vicinal SH-groups, stimulated the rate of 2-deoxy-D-glucose uptake by a factor of 4 to 8 in these cells, while… CONTINUE READING