Phenylacetate and benzoate clearance in a hyperammonemic infant on sequential hemodialysis and hemofiltration

@article{Bunchman2007PhenylacetateAB,
  title={Phenylacetate and benzoate clearance in a hyperammonemic infant on sequential hemodialysis and hemofiltration},
  author={Timothy Edward Bunchman and G Barletta and John W. Winters and John J. Gardner and Teri L. Crumb and Kevin D. McBryde},
  journal={Pediatric Nephrology},
  year={2007},
  volume={22},
  pages={1062-1065}
}
An infant with a suspected inborn metabolism error was treated with a metabolic cocktail of intravenous sodium phenylacetate (NaPh) and sodium benzoate (NaBz) for hyperammonemia. Sequential hemodialysis (HD) then hemofiltration (HF) was performed due to hyperammonemia. Dialytic and convective clearance (K; ml/min) of ammonia, NaPh, and NaBz was measured. The K of ammonia was 57 and 37 for HD and HF, respectively. The K of NaBz was 37 and 12 for HD and HF, respectively. The K of NaPh was 38 and… CONTINUE READING