Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function.

@article{Mele2017PhenylvalerolactonesFC,
  title={Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function.},
  author={Laura Mele and Stefania Carobbio and Nicoletta Brindani and Claudio Curti and Sergio Rodr{\'i}guez-Cuenca and Guillaume Bidault and Pedro Mena and Ilaria Zanotti and M. Vacca and Antonio Vidal-Puig and Daniele Del Rio},
  journal={Molecular nutrition & food research},
  year={2017},
  volume={61 9}
}
SCOPE Consumption of products rich in flavan-3-ols, such as tea and cocoa, has been associated with decreased obesity, partially dependent on their capacity to enhance energy expenditure. Despite these phenolics having been reported to increase the thermogenic program in brown and white adipose tissue, flavan-3-ols are vastly metabolised in vivo to phenyl-γ-valerolactones. Therefore, we hypothesize that phenyl-γ-valerolactones may directly stimulate the differentiation and the activation of… CONTINUE READING
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