Phentolamine and structurally related compounds selectively antagonize the vascular actions of the K+ channel opener, cromromakalim.

@article{McPherson1989PhentolamineAS,
  title={Phentolamine and structurally related compounds selectively antagonize the vascular actions of the K+ channel opener, cromromakalim.},
  author={Grant A. McPherson and James A. S. Angus},
  journal={British journal of pharmacology},
  year={1989},
  volume={97 3},
  pages={941-9}
}
1. The effects of cromakalim, a novel vasodilator agent believed to open K+ channels, were studied in a range of large and small arteries in vitro. In dog isolated coronary artery, precontracted with U46619 (a thromboxane A2-mimetic), cromakalim caused concentration-dependent relaxation which could be inhibited by phentolamine (10-100 microM). 2. The ability of phentolamine to antagonize cromakalim was selective since it did not affect responses to a number of other vasodilators including… CONTINUE READING
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