Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.

@article{Chou2019PhentolamineRE,
  title={Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.},
  author={An-Kuo Chou and C. Chiu and Yu-Wen Chen and Jhi-Joung Wang and C. Hung},
  journal={Anesthesia and analgesia},
  year={2019},
  volume={128 6},
  pages={
          1336-1343
        }
}
BACKGROUND The objective of the experiment was to assess the antinociceptive effect of dibucaine, bupivacaine, and epinephrine. To assess the mechanism of action of the interaction between dibucaine and epinephrine, phentolamine, a nonselective α-adrenergic antagonist, was added to the mixture. METHODS We assessed sensory blockade with these drugs by injecting 0.6 mL of drug-in-saline in the dorsal thoracolumbar area of rats; pinprick of the "wheal" formed by the injectate was the area… Expand
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