Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.

  title={Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.},
  author={An-Kuo Chou and Chong-Chi Chiu and Yu-Wen Chen and Jhi-Joung Wang and Ching-Hsia Hung},
  journal={Anesthesia and analgesia},
  volume={128 6},
BACKGROUND The objective of the experiment was to assess the antinociceptive effect of dibucaine, bupivacaine, and epinephrine. To assess the mechanism of action of the interaction between dibucaine and epinephrine, phentolamine, a nonselective α-adrenergic antagonist, was added to the mixture. METHODS We assessed sensory blockade with these drugs by injecting 0.6 mL of drug-in-saline in the dorsal thoracolumbar area of rats; pinprick of the "wheal" formed by the injectate was the area… Expand
3 Citations
Antimalarial primaquine for skin infiltration analgesia in rats.
Primaquine and chloroquine have greater potency and longer lasting skin analgesia when compared with lidocaine, while the other antimalarials display a similar potency in comparison with lidOCaine. Expand
Chloroquine for prolonged skin analgesia in rats
Chloroquine is not as potent as bupivacaine, but acts as an infiltrative anesthetic for a longer duration of time and is more potent and effective when used in combination with epinephrine. Expand
Isobologram Analysis: A Comprehensive Review of Methodology and Current Research
The principle of isobologram analysis and its application in drug interaction evaluation are summarized and the applications of the similar cotoxicity coefficient and fractional inhibitory concentration index in the evaluation of drug interaction are reviewed. Expand


Digital Necrosis After Lidocaine and Epinephrine Injection in the Flexor Tendon Sheath Without Phentolamine Rescue.
All surgeons who use epinephrine in the finger should be prepared to reverse vasoconstriction with phentolamine rescue if there is persistently inadequate perfusion of the fingertip. Expand
Isobolographic analysis of the cutaneous antinociceptive interaction between bupivacaine co-injected with serotonin in rats.
Preclinical data demonstrated that serotonin is less potent in eliciting cutaneous antinociceptive effects but has the similar duration of action, compared with bupivacaine. Expand
Clonidine as an adjuvant for propranolol enhances its effect on infiltrative cutaneous analgesia in rats
It is demonstrated that propranolol is less potent than bupivacaine as an infiltrative anesthetic and has a significant peripheral action in increasing the depth and duration of action on infiltrative cutaneous analgesia. Expand
Cutaneous synergistic analgesia of bupivacaine in combination with dopamine in rats
Dopamine added to the bupivacaine preparation resulted in a synergistic analgesic effect, and the pre-clinical data showed that dopamine produced a dose-dependent effect in producing cutaneous analgesia. Expand
Ifenprodil for prolonged spinal blockades of motor function and nociception in rats.
It is demonstrated that ifenprodil produces a dose-dependent local anesthetic effect in spinal anesthesia, and shows a more sensory-selective duration of action over motor block, whereas the duration of anesthesia is significantly longer with ifen Prodil than with bupivacaine. Expand
Synergistic Effects of Serotonin or Dopamine Combined With Lidocaine at Producing Nociceptive Block in Rats
Serotonin has a better potency with a much longer duration of action compared with lidocaine at provoking cutaneous analgesia and coadministration of serotonin or dopamine with lidOCaine produced a synergistic effect. Expand
Propranolol combined with dopamine has a synergistic action in intensifying and prolonging cutaneous analgesia in rats.
It is demonstrated that the action of propranolol and dopamine was dose dependent to skin infiltrative analgesia and dopamine produced a lesser potency but a comparable duration of cutaneous analgesia compared to proPRanolol. Expand
Subcutaneous L-tyrosine elicits cutaneous analgesia in response to local skin pinprick in rats.
It is demonstrated that L-tyrosine elicits the local/cutaneous analgesia, and the interaction between L-TYrosine and lidocaine is additive. Expand
[Necrosis in fingers and toes following local anaesthesia with adrenaline--an urban legend?].
  • V. Finsen
  • Medicine
  • Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
  • 2013
There are no grounds for the warning against using lidocaine with adrenaline in fingers and toes; this anaesthetic offers considerable practical advantages and care should be taken with infected fingers or fingers with poor circulation. Expand
Dibucaine Mitigates Spreading Depolarization in Human Neocortical Slices and Prevents Acute Dendritic Injury in the Ischemic Rodent Neocortex
Dibucaine mitigated the effects of spreading depolarization at a concentration that could be well-tolerated therapeutically and is a promising candidate to protect the brain from ischemic injury with an approach that does not rely on the complete abolishment of spreadingdepolarizations. Expand