Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.

  title={Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.},
  author={An-Kuo Chou and C. Chiu and Yu-Wen Chen and Jhi-Joung Wang and C. Hung},
  journal={Anesthesia \& Analgesia},
BACKGROUND The objective of the experiment was to assess the antinociceptive effect of dibucaine, bupivacaine, and epinephrine. To assess the mechanism of action of the interaction between dibucaine and epinephrine, phentolamine, a nonselective α-adrenergic antagonist, was added to the mixture. METHODS We assessed sensory blockade with these drugs by injecting 0.6 mL of drug-in-saline in the dorsal thoracolumbar area of rats; pinprick of the "wheal" formed by the injectate was the area… Expand
Dopamine enhancement of dextrorphan-induced skin antinociception in response to needle pinpricks in rats.
Dopamine produced a synergistic effect on dextrorphan-mediated antinociception, and prolonged dextorkrorphan's ant inociceptive duration. Expand
Isobologram Analysis: A Comprehensive Review of Methodology and Current Research
The principle of isobologram analysis and its application in drug interaction evaluation are summarized and the applications of the similar cotoxicity coefficient and fractional inhibitory concentration index in the evaluation of drug interaction are reviewed. Expand


Isobolographic analysis of the cutaneous antinociceptive interaction between bupivacaine co-injected with serotonin in rats.
Preclinical data demonstrated that serotonin is less potent in eliciting cutaneous antinociceptive effects but has the similar duration of action, compared with bupivacaine. Expand
The Addition of Dilute Epinephrine Produces Equieffectiveness of Bupivacaine Enantiomers for Cutaneous Analgesia in the Rat
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Propranolol combined with dopamine has a synergistic action in intensifying and prolonging cutaneous analgesia in rats.
It is demonstrated that the action of propranolol and dopamine was dose dependent to skin infiltrative analgesia and dopamine produced a lesser potency but a comparable duration of cutaneous analgesia compared to proPRanolol. Expand
Cutaneous synergistic analgesia of bupivacaine in combination with dopamine in rats
Dopamine added to the bupivacaine preparation resulted in a synergistic analgesic effect, and the pre-clinical data showed that dopamine produced a dose-dependent effect in producing cutaneous analgesia. Expand
Amitriptyline for Prolonged Cutaneous Analgesia in the Rat
Amitriptyline is a longer-acting local anesthetic compared with bupivacaine for cutaneous infiltration and its analgesic effectiveness is significantly enhanced by epinephrine. Expand
Ifenprodil for prolonged spinal blockades of motor function and nociception in rats.
It is demonstrated that ifenprodil produces a dose-dependent local anesthetic effect in spinal anesthesia, and shows a more sensory-selective duration of action over motor block, whereas the duration of anesthesia is significantly longer with ifen Prodil than with bupivacaine. Expand
Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system.
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Vasoactive characteristics of bupivacaine and levobupivacaine with and without adjuvant epinephrine in peripheral human skin.
Bupivacaine and levobupvacaine have a biphasic vascular effect when injected intradermally, with subclinical doses causing net vasoconstriction, and the addition of epinephrine decreases these responses markedly. Expand
Clonidine as an adjuvant for propranolol enhances its effect on infiltrative cutaneous analgesia in rats
It is demonstrated that propranolol is less potent than bupivacaine as an infiltrative anesthetic and has a significant peripheral action in increasing the depth and duration of action on infiltrative cutaneous analgesia. Expand
Synergistic Effects of Serotonin or Dopamine Combined With Lidocaine at Producing Nociceptive Block in Rats
Serotonin has a better potency with a much longer duration of action compared with lidocaine at provoking cutaneous analgesia and coadministration of serotonin or dopamine with lidOCaine produced a synergistic effect. Expand