Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release

@article{Schulz1988PhentolamineAD,
  title={Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release},
  author={A. Schulz and Arnold Hasselblatt},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1988},
  volume={337},
  pages={637-643}
}
We investigated the effects of phentolamine and another more selective α2-adrenoceptor antagonist, rauwolscine, on insulin release in vivo (in female Wistar-rats) and in vitro (in perfused rat pancreas and in isolated perifused mouse islets). Phentolamine was found to significantly increase glucose-induced insulin release. On the other hand, rauwolscine failed to do so, when applied in a concentration that effectively antagonized the inhibitory effect of clonidine. These results demonstrate… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Wird auch unter Ruhebedingungen die Insulinabgabe durch einen dauernden hemmenden sympathischen Tonus gedrosselt ? In : Mehnert H , Schlierf G , Sch 6 ffling K ( eds )

  • A Hasselblatt
  • Akt Endokrin Stoffw
  • 1987

Wird auch unter Ruhebedingungen die Insulinabgabe durch einen dauernden hemmenden sympathischen Tonus gedrosselt? In: Mehnert H, Schlierf G, Sch6ffling K (eds) Akt Endokrin Stoffw

  • A Hasselblatt
  • 1987

Effects of c~-adrenoceptor blockade by phentolamine on basal and stimulated insulin secretion in the mouse

  • I Lundquist
  • Acta Physiol Scand
  • 1985

Effects of isoprenaline and glucagon on insulin secretion from pancreatic islets

  • S Zielmann, G Schiitte, S Lenzen, U Panten
  • Naunyn-Schmiedeberg's Arch Pharmacol 329:
  • 1985

Selective ~2 receptor blockade facilitates the insulin response to adrenaline but not to glucose in man

  • AD Struthers, DC Brown, M JBrown, B Schumer, SR Bloom
  • Clin Endocrinol
  • 1985

Effects of ~1-, ~2- and /3-adrenoceptor blockers on insulin secretion in the rat

  • B Ahrn, I Lundquist, J Jirhult
  • Acta Endocrinol
  • 1984

Similar Papers

Loading similar papers…