Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.

@article{Shaw2001PhenserineRT,
  title={Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.},
  author={Karen T Y Shaw and Tadanobu Utsuki and Joseph Rogers and Qing Yu and Kumar Sambamurti and Arnold Brossi and Y W Ge and Debomoy K. Lahiri and Nigel H. Greig},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 13},
  pages={
          7605-10
        }
}
The reduction in levels of the potentially toxic amyloid-beta peptide (Abeta) has emerged as one of the most important therapeutic goals in Alzheimer's disease. Key targets for this goal are factors that affect the expression and processing of the Abeta precursor protein (betaAPP). Earlier reports from our laboratory have shown that a novel cholinesterase inhibitor, phenserine, reduces betaAPP levels in vivo. Herein, we studied the mechanism of phenserine's actions to define the regulatory… CONTINUE READING
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