Phenoxybenzamine Is Neuroprotective in a Rat Model of Severe Traumatic Brain Injury

Abstract

Phenoxybenzamine (PBZ) is an FDA approved α-1 adrenergic receptor antagonist that is currently used to treat symptoms of pheochromocytoma. However, it has not been studied as a neuroprotective agent for traumatic brain injury (TBI). While screening neuroprotective candidates, we found that phenoxybenzamine reduced neuronal death in rat hippocampal slice… (More)
DOI: 10.3390/ijms15011402

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