Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats.

@article{Lin2001PhenotypingOI,
  title={Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats.},
  author={J M Lin and Henrik Orts{\"a}ter and Hossein Fakhrai-Rad and Joakim Galli and Holger Luthman and Peter Bergsten},
  journal={Diabetes},
  year={2001},
  volume={50 12},
  pages={2737-43}
}
The major diabetes quantitative trait locus (Niddm1), which segregates in crosses between GK rats affected with spontaneous type 2-like diabetes and normoglycemic F344 rats, encodes at least two different diabetes susceptibility genes. Congenic strains for the two subloci (Niddm1f and Niddm1i) have been generated by transfer of GK alleles onto the genome of F344 rats. Whereas the Niddm1f phenotype implicated insulin resistance, the Niddm1i phenotype displayed diabetes related to insulin… CONTINUE READING

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