Phenotyping methods for determining HIV tropism and applications in clinical settings.

  title={Phenotyping methods for determining HIV tropism and applications in clinical settings.},
  author={St{\'e}phanie Raymond and Pierre Delobel and Jacques Izopet},
  journal={Current opinion in HIV and AIDS},
  volume={7 5},
PURPOSE OF REVIEW HIV-1 enters CD4-expressing cells via one or both of the chemokine receptors CCR5 and CXCR4. Specific CCR5 antagonists are now in clinical use, but only for CCR5-tropic viruses. Hence, several methods have been developed for assessing HIV-1 tropism in patients who are candidates for CCR5 antagonists. This article reviews current data on phenotypic assays of tropism. RECENT FINDINGS Phenotypic assays are still used as reference, although genotypic methods have improved. The… CONTINUE READING

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