Corpus ID: 20411482

Phenotypic variation of retinal pigment epithelium in age-related macular degeneration.

@article{Guidry2002PhenotypicVO,
  title={Phenotypic variation of retinal pigment epithelium in age-related macular degeneration.},
  author={C. Guidry and N. Medeiros and C. Curcio},
  journal={Investigative ophthalmology & visual science},
  year={2002},
  volume={43 1},
  pages={
          267-73
        }
}
PURPOSE To determine whether retinal pigment epithelium (RPE) in eyes with age-related macular degeneration (ARMD) express vimentin and alpha smooth muscle actin (alphaSMA), two cytoskeletal proteins associated with phenotypic variation in culture. METHODS Six eyes with late ARMD and three age-matched control eyes were preserved in buffered 4% paraformaldehyde and cryosectioned at 10 microm. Stages of RPE morphology and pigmentation were assessed by the Alabama Age-Related Macular… Expand
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