Phenotypic switching of Escherichia coli cells containing cyclic digenic systems with negative feedback upon changes in cultivation conditions

@article{Stupak2010PhenotypicSO,
  title={Phenotypic switching of Escherichia coli cells containing cyclic digenic systems with negative feedback upon changes in cultivation conditions},
  author={Eugeniu{\vs} Stupak and I. V. Stupak},
  journal={Russian Journal of Genetics},
  year={2010},
  volume={46},
  pages={536-540}
}
One of the mechanisms for the epigenetic control of cell phenotypes is based on switching the functioning regimes of bistable gene networks, which can maintain the two alternative levels of gene expression under the same conditions. Cyclic digenic systems with negative feedback represent an example of a simple bistable gene network. Cells carrying artificial cyclic digenic systems on plasmids inherit each alternative phenotype upon exponential growth on rich medium during several cell… CONTINUE READING

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