Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling.

@article{Barkan2011PhenotypicRO,
  title={Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling.},
  author={Batya Barkan and Yoel Kloog and Marcelo Ehrlich},
  journal={Molecular cancer therapeutics},
  year={2011},
  volume={10 8},
  pages={1317-26}
}
Neurofibromin-deficient (Nf1(-/-)) malignant peripheral nerve sheath tumors (MPNST) are highly invasive, refractory to chemotherapy, and characterized by overactivated Ras. Ras activates mitogenic pathways and regulates morphogenic programs--such as those induced by bone morphogenetic proteins (BMP) and TGF-β. The role of such a cross-talk in determining… CONTINUE READING