Phenotypic plasticity and the epigenetics of human disease

@article{Feinberg2007PhenotypicPA,
  title={Phenotypic plasticity and the epigenetics of human disease},
  author={A. Feinberg},
  journal={Nature},
  year={2007},
  volume={447},
  pages={433-440}
}
It is becoming clear that epigenetic changes are involved in human disease as well as during normal development. A unifying theme of disease epigenetics is defects in phenotypic plasticity — cells' ability to change their behaviour in response to internal or external environmental cues. This model proposes that hereditary disorders of the epigenetic apparatus lead to developmental defects, that cancer epigenetics involves disruption of the stem-cell programme, and that common diseases with late… Expand
Chapter 8 – The Human Epigenome—Implications for the Understanding of Human Disease
TLDR
This chapter provides an overview of how epigenetic factors contribute to the development of human diseases, such as abnormal imprinting-causative pathologies, cancer malignancies, as well as autoimmune, cardiovascular, and neurological disorders. Expand
The Human Epigenome—Implications for the Understanding of Human Disease
TLDR
This chapter provides an overview of how epigenetic factors contribute to the development of human diseases, such as abnormal imprinting-causative pathologies, cancer malignancies, as well as autoimmune, cardiovascular, and neurological disorders. Expand
Epigenetics and environment: a complex relationship.
TLDR
The possible impact of epigenetic changes on physiological and pathophysiological processes, depending in part on whether these changes occur during embryonic development or adulthood are discussed. Expand
Epigenetics of Renal Development and Disease
TLDR
This work states that post-translational modifications to DNA and histones in the nucleosome core form characteristic epigenetic codes which are distinct for self-renewing and primed progenitor cell populations, which forms the basis of cell lineage specification in multicellular organisms. Expand
Epigenetic biomarker development.
  • C. Bock
  • Biology, Medicine
  • Epigenomics
  • 2009
TLDR
A systematic approach to epigenetic biomarker development is outlined and key bioinformatic tools that facilitate discovery, optimization and validation of novel biomarkers are highlighted. Expand
Epigenetic mechanisms in development, inheritance and disease
TLDR
An overview of the major epigenetic signaling pathways and their contribution to development and disease is provided. Expand
Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity
TLDR
Different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment are described. Expand
The role of epigenetics in personalized medicine: challenges and opportunities
TLDR
To realize the promise of personalized medicine, both genetic and epigenetic diagnostic testing will be required, and the advances that have been made as well as the challenges for the future are discussed. Expand
Paediatrician’s guide to epigenetics
TLDR
Paediatricians need to be able to interpret epigenetic research critically, in order to use the potential advances brought about through epigenetic studies while appreciating their limitations. Expand
The role of epigenetics in aging and age-related diseases
TLDR
Current knowledge about epigenetic modifications in aging and age-related diseases and future directions in the field are discussed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 121 REFERENCES
Epigenetics, disease, and therapeutic interventions
TLDR
The role of epigenetic changes in disease development, and recent advances in the therapeutic modification of epigenetics marks are reviewed. Expand
The epigenetic progenitor origin of human cancer
TLDR
This work suggests that non-neoplastic but epigenetically disrupted stem/progenitor cells might be a crucial target for cancer risk assessment and chemoprevention. Expand
An integrated epigenetic and genetic approach to common human disease.
TLDR
An approach to common human disease is proposed that incorporates epigenetic variation into genetic studies and might help to explain the late onset and progressive nature of most common diseases, the quantitative nature of complex traits and the role of environment in disease development, which a purely sequence-based approach might not. Expand
The history of cancer epigenetics
TLDR
This timeline traces the field from its conception to the present day and addresses the genetic basis of epigenetic changes — an emerging area that promises to unite cancer genetics and epigenetics, and might serve as a model for understanding the epigenetic basis of human disease more generally. Expand
Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized
TLDR
In vitro assays and microrray studies have delineated the potential molecular mechanisms of MeCP2 function, and have indicated a role in the transcriptional silencing of specific target genes. Expand
The fundamental role of epigenetic events in cancer
TLDR
This review discusses patterns of DNA methylation and chromatin structure in neoplasia and the molecular alterations that might cause them and/or underlie altered gene expression in cancer. Expand
Distinct epigenetic changes in the stromal cells of breast cancers
TLDR
A new method, methylation-specific digital karyotyping, was developed and applied to epithelial and myoepithelial cells, stromal fibroblasts from normal breast tissue, and in situ and invasive breast carcinomas and showed that distinct epigenetic alterations occur in all three cell types during breast tumorigenesis, suggesting that epigenetic changes have a role in the maintenance of the abnormal cellular microenvironment in breast cancer. Expand
Epigenetics and the Environment
TLDR
It is proposed that DNA hypo‐ and hypermethylation are both important in the development of arsenic‐induced cancers, and heightened awareness by toxicologists of the importance of epigenetics in normal human development and in carcinogenesis should lead to the identification of other toxicants that manifest their effects via epigenetic mechanisms. Expand
Induction of Tumors in Mice by Genomic Hypomethylation
TLDR
Results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability. Expand
The emerging science of epigenomics.
TLDR
A number of new epigenomic strategies are emerging to exploit microarray formats with varying substrate choice, pre-processing and data analysis designed to detect large numbers of variations in DNA methylation and chromatin modification. Expand
...
1
2
3
4
5
...