Phenotypic modulation of vascular smooth muscle cells during medial arterial calcification: a role for endothelin?

@article{Essalihi2004PhenotypicMO,
  title={Phenotypic modulation of vascular smooth muscle cells during medial arterial calcification: a role for endothelin?},
  author={Rachida Essalihi and Vincent Ouellette and Huy Dao and Marc D McKee and Pierre Moreau},
  journal={Journal of cardiovascular pharmacology},
  year={2004},
  volume={44 Suppl 1},
  pages={S147-50}
}
We have previously shown that an endothelin receptor antagonist can regress medial arterial calcification in a rat model. The aim of this study was to characterize the phenotypic changes of vascular smooth muscle cells during calcification and mineral loss, in order to understand better the underlying mechanisms. Control Wistar rats were compared with rats treated only with warfarin/ vitamin K1 (15 mg/kg per day) for 8 weeks, or in combination with darusentan (30 mg/kg per day) for the final 4… CONTINUE READING

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