Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix

@article{Madri1988PhenotypicMO,
  title={Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix},
  author={Joseph A. Madri and Bruce M. Pratt and Aimee Marie Tucker},
  journal={The Journal of Cell Biology},
  year={1988},
  volume={106},
  pages={1375 - 1384}
}
Transforming growth factor beta (TGF-beta) is angiogenic in vivo. In vitro, endothelial cell proliferation is inhibited by TGF-beta. We have correlated this inhibitory effect with an increase in cellular fibronectin synthesis and deposition in a two-dimensional culture system using specific matrix coatings. The inhibitory effect was mimicked by addition of soluble fibronectin to cultures. In contrast, TGF-beta was found to elicit the formation of tube-like structures (mimicking angiogenesis… CONTINUE READING

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Growth Factors and the Cardiovascular System

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