Phenotypic modulation by fibronectin enhances the angiotensin II-generating system in cultured vascular smooth muscle cells.

Abstract

We previously demonstrated that homogeneous cultures of vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats produce angiotensin II (Ang II) in response to increases in the levels of angiotensinogen, cathepsin D, and angiotensin-converting enzyme (ACE). The change of VSMCs from the contractile to the synthetic phenotype increased the… (More)

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Cite this paper

@article{Hu2000PhenotypicMB, title={Phenotypic modulation by fibronectin enhances the angiotensin II-generating system in cultured vascular smooth muscle cells.}, author={W. Y. Hu and Nobuo Fukuda and Chikara Satoh and Teng Jian and Ayako Kubo and Mizuho Nakayama and Hirobumi Kishioka and Katsuo Kanmatsuse}, journal={Arteriosclerosis, thrombosis, and vascular biology}, year={2000}, volume={20 6}, pages={1500-5} }