Phenotypic modulation by Legionella pneumophila upon infection of macrophages.

  title={Phenotypic modulation by Legionella pneumophila upon infection of macrophages.},
  author={Yousef Abu Kwaik and Barry I. Eisenstein and N. Cary Engleberg},
  journal={Infection and immunity},
  volume={61 4},
Since many pathogenic bacteria manifest a coordinate regulation of gene expression in response to different environmental stimuli, we examined the phenotypic response of Legionella pneumophila to infection of macrophage-like U937 cells. Intracellular L. pneumophila was radiolabeled, and cell extracts were subjected to two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. At least 35 Legionella proteins were selectively induced during infection of macrophages, and one of… CONTINUE READING


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