Phenotypic models of T cell activation

@article{Lever2014PhenotypicMO,
  title={Phenotypic models of T cell activation},
  author={M. Lever and P. Maini and P. Merwe and Omer Dushek},
  journal={Nature Reviews Immunology},
  year={2014},
  volume={14},
  pages={619-629}
}
T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on the binding parameters that govern the interactions between T cell receptors (TCRs) and peptide–MHC complexes (pMHC complexes). Despite extensive experimental studies, the relationship between the TCR–pMHC binding parameters and T cell activation remains controversial. To make sense of conflicting experimental data, a variety of verbal and mathematical models have been proposed. However, it is… Expand
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