Phenotypic involvement in females with the FMR1 gene mutation.

@article{Riddle1998PhenotypicII,
  title={Phenotypic involvement in females with the FMR1 gene mutation.},
  author={J E Riddle and Ayesha Cheema and W E Sobesky and Shelia C. Gardner and Annette Kimball Taylor and Bruce F. Pennington and Randi Hagerman},
  journal={American journal of mental retardation : AJMR},
  year={1998},
  volume={102 6},
  pages={590-601}
}
Fragile X syndrome is the most common from of inherited mental retardation. Approximately half of females with the full mutation have significant cognitive deficits, whereas females with the premutation do not. Phenotypic effects seen in 281 females (IQs from 64 to 139) were analyzed. Results showed that females with the full mutation differ significantly from controls on selected anthropometric measurements, physical index score, and various behavioral features. Females with the premutation… CONTINUE READING