Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy.

@article{Shulman2001PhenotypicHT,
  title={Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy.},
  author={Nancy S Shulman and Andrew R. Zolopa and Douglas J. Passaro and Robert W. Shafer and Wei Huang and David K. Katzenstein and Dennis M. Israelski and Nicholas S Hellmann and Christo Petropoulos and Jeannette Whitcomb},
  journal={AIDS},
  year={2001},
  volume={15 9},
  pages={1125-32}
}
BACKGROUND Enhanced susceptibility to non-nucleoside reverse transcriptase inhibitors (NNRTI) was recently described in association with increased resistance to nucleoside analogs (nucleoside reverse transcriptase inhibitors; NRTI). OBJECTIVES To determine the prevalence of NNRTI hypersusceptibility, the genotypic correlates, and its impact on virologic response to efavirenz-based salvage therapy. METHODS Genotype and phenotype testing was performed retrospectively on baseline isolates from… CONTINUE READING

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