Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone.

@article{Roudier2003PhenotypicHO,
  title={Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone.},
  author={Martine P. Roudier and Lawrence D. True and Celestia S. Higano and Hubert Vesselle and William D. Ellis and Peter E. Lange and Robert L. Vessella},
  journal={Human pathology},
  year={2003},
  volume={34 7},
  pages={
          646-53
        }
}
To better understand the clinical and pathologic features of end-stage, androgen-independent carcinoma of the prostate (CaP), we performed rapid autopsies on 14 men who died of progressive CaP and recorded relevant clinical data. The timing of tumor progression varied widely. The median time to androgen independence was 2 years (range, 4 months to 13.6 years). The median survival after androgen independence was 1 year (range, 1 month to 3.6 years). Because osseous metastases are prevalent in… CONTINUE READING

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