Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study

@article{Chi2011PhenotypicHO,
  title={Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study},
  author={Adriano Chi{\`o} and Andrea Calvo and Cristina Moglia and Letizia Mazzini and Gabriele Mora},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2011},
  volume={82},
  pages={740 - 746}
}
  • A. Chiò, A. Calvo, +2 authors G. Mora
  • Published 14 March 2011
  • Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
Background Different amyotrophic lateral sclerosis (ALS) phenotypes have been recognised, marked by a varying involvement of spinal and bulbar upper and lower motor neurons. However, the differential characteristics of these phenotypes are still largely unknown. Objective To define the epidemiology and outcome of ALS phenotypes in a population based setting. Methods All ALS cases incident in two Italian regions were prospectively collected from 1995 to 2004 in an epidemiological register. Cases… Expand

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