Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study

  title={Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study},
  author={A. Chi{\`o} and A. Calvo and C. Moglia and L. Mazzini and G. Mora},
  journal={Journal of Neurology, Neurosurgery & Psychiatry},
  pages={740 - 746}
  • A. Chiò, A. Calvo, +2 authors G. Mora
  • Published 2011
  • Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
  • Background Different amyotrophic lateral sclerosis (ALS) phenotypes have been recognised, marked by a varying involvement of spinal and bulbar upper and lower motor neurons. However, the differential characteristics of these phenotypes are still largely unknown. Objective To define the epidemiology and outcome of ALS phenotypes in a population based setting. Methods All ALS cases incident in two Italian regions were prospectively collected from 1995 to 2004 in an epidemiological register. Cases… CONTINUE READING
    306 Citations
    Variability and prognostic relevance of different phenotypes in amyotrophic lateral sclerosis — Data from a population-based registry
    • 25
    • Highly Influenced
    Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS).
    • 26
    • PDF
    ALS phenotype is influenced by age, sex, and genetics
    • 11
    Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis
    • 124
    Amyotrophic lateral sclerosis: a clinical review
    • 5


    Clinical phenotypes and natural progression for motor neuron disease: Analysis from an Australian database
    • P. Talman, A. Forbes, S. Mathers
    • Medicine
    • Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
    • 2009
    • 55
    ALS motor phenotype heterogeneity, focality, and spread
    • 426
    Incidence of amyotrophic lateral sclerosis in Europe
    • 586
    The natural history of primary lateral sclerosis
    • 259
    • PDF
    El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis
    • B. Brooks, R. Miller, M. Swash, T. Munsat
    • Medicine
    • Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
    • 2000
    • 3,578
    Latent Cluster Analysis of ALS Phenotypes Identifies Prognostically Differing Groups
    • 55
    • PDF
    Prognosis of amyotrophic lateral sclerosis with respiratory onset
    • 117