Phenotypic heterogeneity, novel diagnostic markers, and target expression profiles in normal and neoplastic human mast cells.

@article{Valent2010PhenotypicHN,
  title={Phenotypic heterogeneity, novel diagnostic markers, and target expression profiles in normal and neoplastic human mast cells.},
  author={Peter Valent and Sabine Cerny-Reiterer and Harald Herrmann and Irina Mirkina and Tracy I George and Karl Sotlar and Wolfgang R Sperr and H P Horny},
  journal={Best practice & research. Clinical haematology},
  year={2010},
  volume={23 3},
  pages={369-78}
}
Mast cells (MC) are specialized immune cells that play a key role in anaphylactic reactions. Growth, differentiation, and function of these cells are regulated by a complex network of cytokines, surface receptors, signaling molecules, the microenvironment, and the genetic background. A number of previous and more recent data suggest that MC are heterogeneous in terms of cytokine-regulation, expression of cytoplasmic and cell surface antigens, and response to ligands. MC heterogeneity is often… CONTINUE READING