Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model

@article{MinOo2004PhenotypicEO,
  title={Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model},
  author={Gundula Min-Oo and Audray Fortin and M Tam and Philippe Gros and MM Stevenson},
  journal={Genes and Immunity},
  year={2004},
  volume={5},
  pages={168-175}
}
  • Gundula Min-Oo, Audray Fortin, +2 authors MM Stevenson
  • Published in Genes and Immunity 2004
  • Biology, Medicine
  • The recombinant congenic mouse strains AcB55 and AcB61 are extremely resistant to malaria (Plasmodium chabaudi AS) despite the presence of susceptibility alleles at the known Char1/Char2 resistance loci. Resistance in AcB55 and AcB61 is controlled by a locus on chromosome 3 (Char4) shown to be allelic with or tightly linked to a loss-of-function mutation in pyruvate kinase (Pklr). AcB55 and AcB61 show important splenomegaly prior to infection caused by the expansion of the red pulp, and display… CONTINUE READING

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