Phenotypic effects of the "mini-muscle" allele in a large HR x C57BL/6J mouse backcross.

@article{Hannon2008PhenotypicEO,
  title={Phenotypic effects of the "mini-muscle" allele in a large HR x C57BL/6J mouse backcross.},
  author={Robert M. Hannon and Scott A Kelly and Kevin M Middleton and Erik Michael Wilhelm Kolb and Daniel Pomp and Theodore Garland},
  journal={The Journal of heredity},
  year={2008},
  volume={99 4},
  pages={349-54}
}
From outbred Hsd:ICR mice, we selectively bred 4 replicate lines for high running (High-Runner [HR] lines) on wheels while maintaining 4 nonselected lines as controls (C lines). An apparent Mendelian recessive, the "mini-muscle" (MM) allele, whose main phenotypic effect is to reduce hindlimb muscle mass by 50%, was discovered in 2 HR lines and 1 C line. This gene of major effect has gone to fixation in one selected line, remains polymorphic in another, and is now undetectable in the one C line… CONTINUE READING
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