Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.

@article{Desbonnet2012PhenotypicEO,
  title={Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.},
  author={Lieve Desbonnet and Colm M P O'Tuathaigh and Gerard Clarke and Claire O'Leary and Emilie Marty Petit and Niamh Clarke and Orna Tighe and Donna Lai and Richard Harvey and John F Cryan and Timothy G Dinan and John L Waddington},
  journal={Brain, behavior, and immunity},
  year={2012},
  volume={26 4},
  pages={660-71}
}
There is a paucity of animal models by which the contributions of environmental and genetic factors to the pathobiology of psychosis can be investigated. This study examined the individual and combined effects of chronic social stress during adolescence and deletion of the schizophrenia risk gene neuregulin-1 (NRG1) on adult mouse phenotype. Mice were… CONTINUE READING