Phenotypic dynamics of macrophage subpopulations during human experimental gingivitis.

  title={Phenotypic dynamics of macrophage subpopulations during human experimental gingivitis.},
  author={H H Topoll and Gabriele Zwadlo and Dieter Lange and Clemens Sorg},
  journal={Journal of periodontal research},
  volume={24 2},
The purpose of the present study was to investigate whether functionally different macrophages are present in clinically healthy gingiva and during human experimental gingivitis. Eight male probands were introduced to an oral hygiene program until all reached mean Plaque and Gingival Index scores approaching zero. During the following 19 days all oral hygiene was abandoned. At d -14, 0, 2, 4, 7, 11 and 19 clinical indices and gingival biopsies were taken. Cryostat sections were incubated with… CONTINUE READING
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