Phenotypic diversity of neoplastic chondrocytes and extracellular matrix gene expression in cartilaginous neoplasms.

@article{Aigner1997PhenotypicDO,
  title={Phenotypic diversity of neoplastic chondrocytes and extracellular matrix gene expression in cartilaginous neoplasms.},
  author={Thomas Aigner and Susanne Dertinger and S I Vornehm and Jayesh Dudhia and Klaus von der Mark and Thomas W. Kirchner},
  journal={The American journal of pathology},
  year={1997},
  volume={150 6},
  pages={2133-41}
}
Chondrocyte differentiation is characterized by distinct cellular phenotypes, which can be identified by specific extracellular matrix gene expression profiles. By applying in situ analysis on the mRNA and protein level in a series of benign and malignant human chondrogenic neoplasms, we were able to identify for the first time different phenotypes of neoplastic chondrocytes in vivo: 1) mature chondrocytes, which synthesized the characteristic cartilaginous extracellular tumor matrix, 2) cells… CONTINUE READING

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