Phenotypic diversity in cultured cerebral microvascular endothelial cells

@article{Rupnick1988PhenotypicDI,
  title={Phenotypic diversity in cultured cerebral microvascular endothelial cells},
  author={Maria A. Rupnick and Andrew B. Carey and Stuart K. Williams},
  journal={In Vitro Cellular & Developmental Biology},
  year={1988},
  volume={24},
  pages={435-444}
}
Diversity exists in both the structure and function of the endothelial cells (EC) that comprise the microvasculature of different organs. Studies of EC have been aided by our ability to first isolate and subsequently establish cultures from microvascularized tissue. After the isolation of microvessel endothelial cells (MEC) derived from rat cerebrum, we observed morphologic differences in colonies of cells that grew in primary cultures. The morphologies ranged from a cobblestone phenotype… CONTINUE READING