Phenotypic differences in viral immune escape explained by linking within-host dynamics to host-population immunity.


Viruses that do not cause life-long immunity persist by evolving rapidly in response to prevailing host immunity. The immune-escape mutants emerge frequently, displacing or co-circulating with native strains even though mutations conferring immune evasion are often detrimental to viral replication. The epidemiological dynamics of immune-escape in acute… (More)
DOI: 10.1016/j.jtbi.2010.05.036


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