Phenotypic differences in subclones and long-term cultures of clonally derived rat bone cell lines.

@article{Bellows1986PhenotypicDI,
  title={Phenotypic differences in subclones and long-term cultures of clonally derived rat bone cell lines.},
  author={Carlton G Bellows and Jaro Sodek and Kaiwen Yao and Jane E. Aubin},
  journal={Journal of cellular biochemistry},
  year={1986},
  volume={31 2},
  pages={153-69}
}
Previous studies with clonally derived populations of cells have shown that cells released from embryonic rat calvaria by enzymatic digestion are heterogeneous with respect to their hormone responsiveness, morphology, and production of matrix components [Aubin JE et al; J. Cell Biol 92:452, 1982]. Several of these clonal populations have been used to study the effects of long-term culture and inter- and intraclonal cell heterogeneity. During continuous subculture, marked changes in collagen… CONTINUE READING