Phenotypic differences between oral and skin fibroblasts in wound contraction and growth factor expression.

@article{Shannon2006PhenotypicDB,
  title={Phenotypic differences between oral and skin fibroblasts in wound contraction and growth factor expression.},
  author={Diane B Shannon and Scott Thomas William McKeown and Fionnuala T. Lundy and Chris R. Irwin},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  year={2006},
  volume={14 2},
  pages={172-8}
}
Wounds of the oral mucosa heal in an accelerated fashion with reduced scarring compared with cutaneous wounds. The differences in healing outcome between oral mucosa and skin could be because of phenotypic differences between the respective fibroblast populations. This study compared paired mucosal and dermal fibroblasts in terms of collagen gel contraction, alpha-smooth muscle actin expression (alpha-SMA), and production of the epithelial growth factors: keratinocyte growth factor (KGF) and… CONTINUE READING