Phenotypic characterization of the human myeloma cell growth fraction.

@article{Robillard2005PhenotypicCO,
  title={Phenotypic characterization of the human myeloma cell growth fraction.},
  author={Nelly Robillard and Catherine Pellat-Deceunynck and R{\'e}gis Bataille},
  journal={Blood},
  year={2005},
  volume={105 12},
  pages={4845-8}
}
In this study we quantified the proliferation rate of normal and malignant plasma cells (PCs) by ex vivo incorporation of 5-bromo-2'-deoxyuridine (BrdU; labeling index, LI) using flow cytometry. We show that all bone marrow PCs, either normal or malignant, include a subset of proliferating PCs present within the CD45(bright) fraction. Indeed, medullary normal and malignant PCs were always heterogeneous for CD45 expression, and proliferation was always restricted primarily to the CD45(bright… CONTINUE READING

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