Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone.

@article{Sanchez2008PhenotypicCO,
  title={Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone.},
  author={Christelle Sanchez and Michelle A Deberg and Akeila Bellahc{\'e}ne and Vincent Castronovo and Philippe Msika and Jean Delcour and J M Crielaard and Yves Edgard Henrotin},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 2},
  pages={442-55}
}
OBJECTIVE To determine the phenotype of osteoblasts from the sclerotic zones of human osteoarthritic (OA) subchondral bone. METHODS Human osteoblasts were isolated from sclerotic or nonsclerotic areas of subchondral bone and cultured for 14 days in monolayer. The expression of 14 genes was investigated by real-time reverse transcription-polymerase chain reaction. The activities of alkaline phosphatase (AP) and transglutaminases (TGases) were quantified by enzymatic assays. C-terminal type I… CONTINUE READING

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