Phenotypic characterization of normal and CML CD34-positive cells: only the most primitive CML progenitors include Ph-neg cells.

@article{Fabritiis1993PhenotypicCO,
  title={Phenotypic characterization of normal and CML CD34-positive cells: only the most primitive CML progenitors include Ph-neg cells.},
  author={Paolo de Fabritiis and Charles Dowding and J. A. Bungey and Andrew Chase and George L D Angus and Richard M. Szydlo and John M. Goldman},
  journal={Leukemia & lymphoma},
  year={1993},
  volume={11 1-2},
  pages={51-61}
}
We studied the sequence of acquisition of CD33, CD38 and HLA-DR antigens on CD34+ cells from marrow and blood of Ph-chromosome positive CML patients and normal marrow. We examined the Ph status of the various CML cell populations. The mean proportions of normal and CML CD34+ cells expressing CD33 and CD38 were not significantly different. However, a… CONTINUE READING