Phenotypic characterization of drug resistance-associated mutations in HIV-1 RT connection and RNase H domains and their correlation with thymidine analogue mutations.

@article{Lengruber2011PhenotypicCO,
  title={Phenotypic characterization of drug resistance-associated mutations in HIV-1 RT connection and RNase H domains and their correlation with thymidine analogue mutations.},
  author={Renan B. Lengruber and Krista A Delviks-Frankenberry and Galina N. Nikolenko and Jessica Leigh Baumann and Andr{\'e} Felipe Santos and Vinay K Pathak and Marcelo Alves Soares},
  journal={The Journal of antimicrobial chemotherapy},
  year={2011},
  volume={66 4},
  pages={702-8}
}
OBJECTIVES HIV-1 reverse transcriptase (RT) mutations associated with antiviral drug resistance have been extensively characterized in the enzyme polymerase domain. Recent studies, however, have verified the involvement of the RT C-terminal domains (connection and RNase H) in drug resistance to RT inhibitors. In this work, we have characterized the correlation of recently described C-terminal domain mutations with thymidine analogue mutations (TAMs), as well as their phenotypic impact on… CONTINUE READING
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